Process Development Scientist
Confidential
Thousand Oaks, CA
Full-time
Science
Posted on June 7, 2020
Amgen Inc.; Process Development Scientist; Thousand Oaks, CA: Support the advancement of Amgen's pipeline of drug candidates from discovery to clinical trials by establishing various mass spectrometry (reduced and non-reduced peptide mapping, intact analysis) and separation (liquid chromatography, capillary electrophoresis, size-exclusion chromatography, ion mobility spectrometry) techniques to identify, characterize, monitor and control different attributes (such as deamidation, oxidation, glycosylation, isomerization etc.) that may impact product efficacy, safety and stability of biological therapeutics. PREPARING SAMPLES AND DESALTING METHODOLOGIES AS APPLIED TO PROTEIN MASS SPECTROMETRY WORKFLOWS IN ANALYZING COMPLEX BIOLOGICAL SAMPLES WITH HIGH DYNAMIC RANGES OF ANALYTES; CONDUCTING PEPTIDE AND PROTEIN SEPARATION TECHNIQUES SUCH AS LIQUID CHROMATOGRAPHY AND ION MOBILITY; OPERATING AND MAINTAINING DIFFERENT TYPES OF MASS SPECTROMETERS (Q-TOF, ORBITRAP) FROM VARIOUS VENDORS INCLUDING WATERS AND THERMO FISHER SCIENTIFIC AND EXPERIENCE WITH VARIOUS FORMS OF DATA ACQUISITION (MS1 ACQUISITION, DATA DEPENDENT ACQUISITION, DATA DEPENDENT ACQUISITION, AND MULTIPLE REACTION MONITORING/PARALLEL REACTION MONITORING); UTILIZING MASS SPECTROMETRY-BASED METHODS FOR PEPTIDE AND PROTEIN QUANTITATION WITH MASS SPECTROMETRY-RELATED DATA ANALYSIS PLATFORMS SUCH AS XCALIBUR, MASSLYNX, MASCOT, PROTEINPROSPECTOR, DRIFTSCOPE AND SOFTWARE PACKAGES FOR MASS SPECTROMETRY-BASED QUANTITATION SUCH AS SKYLINE OR TARGETLYNX; INTERPRETING TANDEM MASS SPECTROMETRY DATA ACQUIRED USING VARIOUS FRAGMENTATION TECHNIQUES SUCH AS CAD/CID, HCD, AND ETD.; AND SEPARATING, IDENTIFYING, QUANTIFYING, CHARACTERIZING OF CHEMICAL LIABILITIES AND POST-TRANSLATIONAL MODIFICATIONS KNOWN TO AFFECT PROTEIN FUNCTION. Interested candidates mail resume to: HR Connect c/o TM Review @ Amgen Inc. 2202 N Westshore Blvd, Ste 650, Tampa, FL 33607 Attn. Job #20516.275